Musculoskeletal Issues/side effects on Sertraline?

Posted , 7 users are following.

   I have been on Sertraline since late May, for gastrointestinal issues, reflux, back/chest sternum pain, and anxiety/depression about my health.  I started on 25mg and am now on 150mg.  Since that point I have gradually felt physically worse musculoskeletal and nervous system wise. 

      It started with tingling pins and needles in extremities, then gradual muscle aches/soreness, joint and bone cracking, and tension/tightness.  My whole body head to toe/both sides is stiff, sore and achy when I get up and fluctuates with severity during the day and week to week. My joints and bones are cracking excessively (deep breaths or movements). I have spine/back soreness and tender points.  My neck has been diagnosed with Neck spasms and a bulging disc (straightened cervical spine - MRI) I have random muscle twitches and mini spasms all throughout my body, but really is hardcore in my calves.  They will spasm and twitch like crazy, especially after use or exercise.  My jaw is fatigued and tight when eating.  My legs feel heavy and muscles are so tight they are cramping at times.  

  I went to 150mg and noticed my neck is stiffer and my calves/ feet are cramping slightly more.  It is not debilitating, but really annoying and concerning.  I have had all sorts of tests and blood work.  The rheumotologist felt it wasn't fibromyalgia due to lack of severity and pain in certain points.  Not one of the million doctors I went to has indicated that it may be sertraline and to get off.  I am losing my mind with whether sertraline could be the cause to many of the musculoskeletal/nerve issues or if it a slow progression of another serious issue.  

   Has anyone had musculoskeletal issues and muscle/joint tension like this, while on SSRI?  The side effect list makes it seem like muscle tension is rare and only when combined with other bad allergic reaction type symptoms.  

0 likes, 6 replies

6 Replies

  • Posted

    yes! Headaches and intense jaw pain/stiffness as well as neck and back.
  • Posted

    Yes typical side effects. Check with your doc for a painkiller. It will eventually wear off.

    Take care

  • Posted

    Im having the exact similar thing, i have a bulging disc and i know its the sertraline, now im here tryna get better doing excercises and taking meds. 
  • Posted

    Hi I know this is an older post but I had the same muscle soreness problems first In my arms then legs then around my abs, all slowly got better, I still have the abdominal pain and soreness sometimes, im on 50mg sertraline by the way 
  • Posted

    Zoloft helped me many years ago for constant panic attacks and depression, I was on it for about 10 years. Since then whenever I try to go back on it, I have neck, back, and extreme knee pain.

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