Tonsillitis is inflammation due to infection of the tonsils. Pharyngitis is inflammation of the oropharynx but not the tonsils. The tonsils tend to atrophy in early adulthood. In laryngitis there are few visible signs of infection but with soreness lower down the throat often associated with a hoarse voice.
- It is a very common condition, most frequent in children aged 5-10 years and young adults between 15 and 25 years.
- A GP with a list of 2,000 can expect to see around 120 cases of sore throat a year with considerable seasonal variation - see the separate Sore Throat article.
- The Scottish Intercollegiate Guidelines Network (SIGN) suggests that only 1 patient in 18 with a sore throat will consult.
These include immune deficiency and a family history of tonsillitis or atopy.
- Pain in the throat is sometimes severe and may last more than 48 hours, along with pain on swallowing.
- Pain may be referred to the ears.
- Small children may complain of abdominal pain.
- Loss of voice or changes in the voice.
- The throat is reddened, the tonsils are swollen and may be coated or have white flecks of pus on them.
- Possibly a high temperature.
- Swollen regional lymph glands.
- Classical streptococcal tonsillitis has an acute onset, headache, abdominal pain and dysphagia.
- Examination shows intense erythema of tonsils and pharynx, yellow exudate and tender, enlarged anterior cervical glands.
Tonsillitis tends to be misdiagnosed, leading to inappropriate treatment with antibiotics.
- If the sore throat is due to a viral infection the symptoms are usually milder and often related to the common cold.
- If due to infection with Coxsackievirus, small blisters develop on the tonsils and the roof of the mouth. The blisters erupt in a few days and are followed by a scab, which may be very painful.
- Infectious mononucleosis (glandular fever) affects teenagers most often. They may be quite unwell with very large and purulent tonsils and a long-lasting lethargy. An enlarged spleen is classically described and infrequently found.
- Herpes simplex virus (HSV) infection, especially in adolescents and young adults.
- In streptococcal infection the tonsils often swell and become coated and the throat is sore. The patient has a temperature, foul-smelling breath and may feel quite ill. The differences are variable and it is impossible to tell on inspection if the infection is viral or bacterial.
- Epiglottitis requires immediate admission.
- Unusual bacteria may be involved, including gonococcal infection.
- Unilateral enlargement of the tonsils may indicate malignancy.
- It is not uncommon for HIV infection to present with ENT symptoms, especially in children. The most common presentations are cervical lymphadenopathy, oro-oesophageal candidiasis and otitis media.
- It is recommended that throat swabs and rapid antigen tests should not be performed routinely.
- There is some validity to the argument that swabs do not differentiate between infection and carriage.
- SIGN states that rapid antigen tests detect the presence of Group A streptococcal antigen on a throat swab within a few minutes but they have poor sensitivity and make little impact on prescribing decisions.
- An adolescent or young adult with a nasty sore throat may well have glandular fever. A Paul-Bunnell or equivalent blood test may be indicated.
Culture of Group A beta-haemolytic streptococcus (GABS) is inefficient as a diagnostic criterion, as it is too slow and it fails to differentiate between infection and carriage. There are four Centor Criteria that may be used:
- History of fever.
- Tonsillar exudates.
- No cough.
- Tender anterior cervical lymphadenopathy.
Patients with one or none of these criteria are unlikely to have GABS. Consideration of antibiotic prescription should be limited to patients with three or four criteria.
- Upper respiratory tract infections are quite infectious and so those with such infections should avoid social contact and stay away from work, especially if feeling unwell.
- Explanation with reassurance that this is a self-limiting condition is sufficient management advice for some patients.
- Gargles are anecdotally helpful but there is no evidence base to support their use.
- 'Watchful waiting' is appropriate for children with mild recurrent sore throats.
- Antipyretic analgesics such as paracetamol and ibuprofen are of value.
- For most patients, antibiotics have little effect on the duration of the condition or the severity of symptoms. The National Institute for Health and Care Excellence (NICE) suggests that indications for antibiotics include:
- Features of marked systemic upset secondary to the acute sore throat.
- Unilateral peritonsillitis.
- A history of rheumatic fever.
- An increased risk from acute infection (such as a child with diabetes mellitus or immunodeficiency).
- Acute tonsillitis with three or more Centor criteria present (see 'Diagnostic criteria', above).
- NICE recommends that a back-up antibiotic prescription may be considered as a treatment option with the following advice:
- An antibiotic not being needed immediately.
- Using the back-up prescription if symptoms do not start to improve within 3-5 days or if they worsen rapidly or significantly at any time.
- Seeking medical help if symptoms worsen rapidly or significantly or the person becomes systemically very unwell.
- In patients with infectious mononucleosis (glandular fever) requiring hospital admission, corticosteroids may have a role when pain and swelling threaten the airway or where there is very severe dysphagia.
Use of antibiotics
Reviews of the literature concur that antibiotics confer no benefit in the majority of patients with sore throat, that the 'numbers needed to treat' warrant a conservative approach in developed countries and that they should be reserved for specific clinical scenarios.
Antibiotics confer relative benefits in the treatment of sore throat. However, the absolute benefits are modest. Protecting sore throat sufferers against suppurative and non-suppurative complications in high-income countries requires treating many patients with antibiotics for one patient to benefit. This number needed to treat to benefit may be lower in low-income countries. Antibiotics shorten the duration of symptoms by about 16 hours overall.
Choice of antibiotic
The antibiotic of choice is a 5-10 day course of phenoxymethylpenicillin. Alternative first choices for penicillin allergy or intolerance are clarithromycin or erythromycin. Amoxicillin should be avoided if there is a possibility of glandular fever. If penicillin-allergic, a 10-day course of clarithromycin is recommended.
Referral criteriaArrange hospital admission, with urgency determined by clinical judgement, for anyone with:
- Breathing difficulty.
- Clinical dehydration.
- Peritonsillar abscess or cellulitis, parapharyngeal abscess, retropharyngeal abscess, or Lemierre's syndrome (as there is a risk of airway compromise or rupture of the abscess).
- Signs of marked systemic illness or sepsis.
- A suspected rare cause such as Kawasaki disease, diphtheria, or yersinial pharyngitis.
NICE has recommended that for people with severe recurrent tonsillitis (a frequency of more than seven episodes per year for one year, five per year for two years, or three per year for three years, and for whom there is no other explanation for the recurrent symptoms), referral to an ear, nose, and throat specialist is advised as there may be a benefit from tonsillectomy in this group..
Tonsillectomy remains a very common ENT operation. Two thirds of tonsillectomies in the UK are performed on children. Tonsils are important lymph tissue which protects the upper airways. Recurrent infection, however, does alter this situation and chronic tonsillitis can turn tonsillar tissue into a nidus for anaerobic bacteria. Tonsillectomy may help to change the oropharyngeal bacterial profile to a more normal pattern.
SIGN has produced its own criteria for tonsillectomy for children and adults, viz:
- Sore throats are due to acute tonsillitis.
- The episodes of sore throat are disabling and prevent normal functioning.
- Seven or more well-documented, clinically significant, adequately treated sore throats in the preceding year; or
- Five or more such episodes in each of the preceding two years; or
- Three or more such episodes in each of the preceding three years.
A six-month period of watchful waiting is appropriate in patients for whom the indications for surgery are not clear-cut.
Surgical methods used
- Cold steel - this is the traditional method which involves removal of the tonsils by blunt dissection followed by haemostasis using ligatures.
- Diathermy - this uses radiofrequency energy applied directly to the tissue. It can be bipolar (the current passes between the two tips of the forceps) or monopolar (the current passes between the forceps' skin and a plate attached to the patient's skin). The heat generated may be used to dissect the tonsils away from the pharyngeal wall and also to promote haemostasis. Diathermy is sometimes used as an adjunct to cold steel surgery to achieve haemostasis.
- Coblation - this involves passing a radiofrequency bipolar electric current through normal saline. The resulting plasma field of sodium ions can be used to dissect tissue by disrupting intercellular bonds and causing tissue vaporisation. This method generates less heat than diathermy.
Tonsillectomy is effective in reducing the number of episodes of sore throat and the number of days with sore throats in children. The gain is more marked in those most severely affected. However, the effect is modest. Although removing the tonsils will prevent tonsillitis, the impact on sore throats due to pharyngitis is much less predictable.
- Peritonsillar abscess.
- Acute otitis media.
- Lancefield's GABS can cause rheumatic fever, Sydenham's chorea, glomerulonephritis and scarlet fever.
- Streptococcal infection may cause a flare-up of guttate psoriasis.
- Enlarged and chronically infected tonsils interfere with children's sleep.
- Complications of tonsillectomy include otitis media and haemorrhage which can be very difficult, especially where there is an undiagnosed bleeding tendency such as haemophilia. Altered taste sensation has been reported.
- Patients who have had tonsillectomy are more susceptible to bulbar poliomyelitis.
The average duration of acute tonsillitis is one week.
One study found that if tonsillectomy does have to be performed in children it produces a positive and durable increase in 'health-related quality of life' measures.
Smoking cessation for parents: the children of parents who smoke have an increased prevalence of upper respiratory tract infections, wheeze, asthma and lower respiratory tract infections.
Further reading and references
; NICE Clinical Guideline (July 2008)
; Scottish Intercollegiate Guidelines Network - SIGN (April 2010)
; NICE CKS, January 2018 (UK access only)
; NICE Guideline (Jan 2018)
; Antibiotics for sore throat. Cochrane Database Syst Rev. 2013 Nov 511:CD000023.
; NICE Evidence Services (UK access only)
; Indications for tonsillectomy: the evidence base and current UK practice. Br J Hosp Med (Lond). 2009 Jun70(6):344-7.
; Oropharyngeal flora changes after tonsillectomy. Otolaryngol Head Neck Surg. 2009 Nov141(5):609-13. Epub 2009 Oct 1.
; Interventional Procedure Guidance, NICE, 2005
; Tonsillectomy or adeno-tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2009 Jan 21(1):CD001802.
; Pediatric obstructive sleep apnea: current management. ORL J Otorhinolaryngol Relat Spec. 200769(6):340-4. Epub 2007 Nov 23.
; Tonsillectomy may cause altered tongue sensation in adult patients. J Laryngol Otol. 2009 May123(5):545-9. Epub 2008 Jul 30.
; The impact of adenotonsillectomy on children's quality of life. Clin Otolaryngol. 2008 Feb33(1):56-9.
; Environmental tobacco smoke (ETS) and respiratory health in children. Eur J Pediatr. 2009 Aug168(8):897-905. doi: 10.1007/s00431-009-0967-3. Epub 2009 Mar 20.